Real Madrid take on Bulgarian champions Ludogorets hoping to extend their excellent recent run.
Los Blancos have recorded four consecutive wins scoring 20 goals and travel to Bulgaria confident of getting another goal fest.
A few players who usually sit on the bench could have a chance to get minutes of play, as Carlo Ancelotti is expected to line-up Isco, Chicharito and Asier Illarramendi against the Razgrad-based side.
James Rodriguez and Toni Kroos could get some rest after an exhausting start of the season.
Los Merengues boss will recover Pepe, who returns to the squad after suffering a muscle injury, but it seems very unlikely that he will feature from the start. Youngster Alvaro Medran is also included. Fabio Coentrao, Sami Khedira and Jese Rodriguez remain on the sidelines.
Real will seek to consolidate their first position atop group B, after having trashed Basel 5-1 in the first game.
However, Ludogorets could put them in trouble, as they did with Liverpool two weeks ago. The Bulgarians showed their defensive grit at Anfield Road and were close to savaging a point.
Playing their first home game, they will be ready to try and record a shock in probably the biggest match in their short history.
Ludogorets: Gospodinov; Caicara, Aleksandrov, Moti, Minev; Aleksandrov, Dyakov, Adriananteina, Misidjan; Bezjak, Marcelinho.
Real Madrid: Casillas; Arbeloa, Varane, Ramos, Marcelo; Modric, Illarramendi, Isco; Bale, Chicharito, Ronaldo.