Zinedine Zidane has included Alvaro Arbeloa in the starting eleven for the first time since he arrived at the first team.
The veteran defender will give Marcelo some rest at left-back. Daniel Carvajal will start at right-back. Meanwhile, Pepe and Sergio Ramos will be the centre-back pair.
With Toni Kroos and James Rodriguez watching the game from home, as they have been left out of the squad to rest, Casemiro, Luka Modric and Isco will form the midfield line.
The other doubt for Zidane was whether to include Borja Mayoral or Lucas Vazquez in the forward line alongside Gareth Bale and Cristiano Ronaldo. The Frenchman has finaly chosen Vazquez, who has been excellent in the past few games.
This is Real Madrid’s starting eleven: Navas; Carvajal, Pepe, Ramos, Arbeloa; Modric, Casemiro, Isco; Vazquez, Ronaldo, Bale.
Meanwhile, Quique Setien will miss playmaker Tana but has recovered Roque Mesa. Former Real Madrid Castilla man William Jose has also made it in the lineup.
This is Las Palmas starting eleven: Varas; Garcia, Bigas, Lemos, Garrido; Nili, El Zhar, Roque Mesa, Viera, Momo; William Jose.